Karlsson registered an assist in the season finale versus the Islanders on Wednesday.
Karlsson scored the game-winning goal in Thursday's 6-5 win over the Red Wings.
Karlsson notched three assists in Saturday's 5-4 win over the Lightning.
Karlsson failed to register a shot in Monday's 5-2 win over the Rangers, extending his goal drought to 18 games.
Karlsson failed to score a goal for the 14th straight game against the Avalanche on Sunday.
Karlsson (illness) will be available to play Saturday against Vegas, per Penguins play-by-play announcer Josh Getzoff.
Karlsson missed Friday's practice because of an illness, Matt Vensel of the Pittsburgh Post-Gazette reports. He's questionable for Saturday's game against Vegas as a result.
Karlsson had an assist in Monday's 3-0 home victory against the Kraken.
Karlsson garnered an assist versus Vancouver in a 4-3 loss Thursday, continuing his five-game point streak.
Karlsson notched two assists, one on the power play, in Thursday's 6-5 win over the Bruins.