Middleton notched three assists while adding three blocked shots and a plus-3 rating in Tuesday's 5-1 win over the Panthers.
Middleton (bruise) will be available for Thursday's Opening Night matchup against the Blue Jackets, Jessi Pierce of NHL.com reports.
Middleton (bruise) took part in Monday's practice session, John Shipley of The Pioneer Press reports.
Middleton (bruise) will not play Friday in Chicago, Michael Russo of The Athletic reports.
Middleton is day-to-day while he heals from a bruise, Michael Russo of The Athletic reports Tuesday.
Middleton signed a four-year, $17.4 million contract extension with Minnesota on Monday, per Darren Dreger of TSN.
Middleton notched an assist in Saturday's 6-2 win over the Sharks.
Middleton (upper body) will return to the lineup Sunday against Nashville, according to Michael Russo of The Athletic.
Middleton netted a goal in a 6-1 win over Nashville on Thursday.
Middleton scored on his only shot and blocked four shots in Sunday's 4-3 overtime loss to the Maple Leafs to wrap up the Global Series in Sweden.