Pezzetta (lower body) won't play against Ottawa on Saturday, Patrick Friolet of RDS reports.
Pezzetta is not available for Tuesday's practice due to a lower-body injury and will be evaluated on a daily basis.
Pezzetta has played in three straight games after suiting up in Monday's 5-4 overtime win over the Canucks.
Pezzetta was scratched for the 18th consecutive game in Saturday's 4-2 loss to the Capitals.
Pezzetta (upper body) is expected to be fully fit ahead of training camp, Eric Engels of Sportsnet reports Monday.
Pezzetta had an assist, two blocked shots and four hits in Sunday's 5-1 win over Seattle.
Pezzetta scored a goal on one shot and added two hits over 10:08 of ice time in Tuesday's 5-2 win over the Capitals.
Pezzetta scored a goal on one shot in Thursday's 6-2 loss to the Senators. He also had one block, three hits and five penalty minutes over 8:47 of ice time.
Pezzetta logged an assist and two hits over 9:01 of ice time in Wednesday's 3-2 shootout loss to Philadelphia.
Pezzetta had an assist and eight hits over 8:25 of ice time in Saturday's 4-3 shootout win over the Rangers.