The San Diego Padres acquired outfielder Jake Marisnick from the Chicago Cubs for pitcher Anderson Espinoza.

The San Diego Padres acquired pitcher Daniel Hudson from the Washington Nationals for pitcher Mason Thompson and infielder Jordy Barley.

The San Diego Padres acquired infielder/outfielder Adam Frazier and cash from the Pittsburgh Pirates for infielder/outfielder Tucupita Marcano, outfielder Jack Suwinski and pitcher Michell Miliano.

The San Diego Padres acquired pitcher James Norwood from the Chicago Cubs for pitcher Dauris Valdez.

In a three-team trade, the San Diego Padres acquired pitcher Joe Musgrove from the Pittsburgh Pirates; the New York Mets acquired pitcher Joey Lucchesi from the Padres; and Pittsburgh acquired outfielder Hudson Head and pitchers Omar Cruz, David Bednar and Drake Fellows from the Padres, and catcher Endy Rodriguez from the Mets.

The New York Yankees acquired outfielder Greg Allen from the San Diego Padres for pitcher James Reeves.

The San Diego Padres acquired pitcher Yu Darvish and catcher Victor Caratini from the Chicago Cubs for pitcher Zach Davies, infielders Reginald Preciado and Yeison Santana, and outfielders Owen Caissie and Ismael Mena.

The San Diego Padres acquired pitcher Blake Snell from the Tampa Bay Rays for catchers Francisco Mejia and Blake Hunt, and pitchers Luis Patino and Cole Wilcox.

The San Diego Padres acquired pitcher Taylor Williams from the Seattle Mariners for a player to be named later (Matt Brash - 09/17/20).

TThe San Diego Padres acquired outfielder Greg Allen, starting pitcher Mike Clevinger and a player to be named later (Matt Waldron - November 09 and 2020) from the Cleveland Indians for infielder Owen Miller, catcher Austin Hedges, outfielder Josh Naylor, pitcher Cal Quantrill, pitcher Gabriel Arias and pitcher Joey Cantillo.

The San Diego Padres acquired catcher/infielder Austin Nola and pitchers Austin Adams and Dan Altavilla from the Seattle Mariners for outfielder Taylor Trammell, pitcher Andres Munoz, infielder Ty France and catcher Luis Torrens.

The San Diego Padres acquired first baseman Mitch Moreland from the Boston Red Sox for outfielder Jeisson Rosario and infielder Hudson Potts.

The San Diego Padres acquired catcher Jason Castro from the Los Angeles Angels for pitcher Gerardo Reyes.

The San Diego Padres acquired pitcher Trevor Rosenthal from the Kansas City Royals for outfielder Edward Olivares and a player to be named later.

The Seattle Mariners acquired pitcher Jimmy Yacabonis from the San Diego Padres for cash.

The San Diego Padres acquired first baseman Yonder Alonso from the Atlanta Braves for cash.

The San Diego Padres acquired pitcher Tim Hill from the Kansas City Royals for outfielder Franchy Cordero and pitcher Ronald Bolanos.

The San Diego Padres acquired infielder Jorge Mateo from the Oakland Athletics for a player to be named later.

The San Diego Padres acquired pitcher Emilio Pagan from the Tampa Bay Rays for outfielder Manuel Margot and catcher Logan Driscoll.

The San Diego Padres acquired outfielder Tommy Pham and infielder/pitcher Jake Cronenworth from the Tampa Bay Rays for outfielder Hunter Renfroe, infielder Xavier Edwards and a player to be named later.

The San Diego Padres acquired infielder Jurickson Profar from the Oakland Athletics for catcher Austin Allen and a player to be named later.

The Milwaukee Brewers acquired infielder Luis Urias, pitcher Eric Lauer and a player to be named later from the San Diego Padres for outfielder Trent Grisham and pitcher Zach Davies.

The Cincinnati Reds acquired outfielder Travis Jankowski from the San Diego Padres for international bonus pool money in 2019-20.

The San Diego Padres acquired pitcher Carl Edwards Jr. from the Chicago Cubs for pitcher Brad Wieck.

In a three-team trade, the Cleveland Indians acquired outfielder Yasiel Puig and pitcher Scott Moss from the Cincinnati Reds, and outfielder Franmil Reyes, pitcher Logan Allen and infielder Victor Nova from the San Diego Padres; the Reds acquired pitcher Trevor Bauer from Cleveland, and the Padres acquired outfielder Taylor Trammell from Cincinnati.

The Philadelphia Phillies acquired infielder/outfielder Jose Pirela from the San Diego Padres for cash.

The Cleveland Indians acquired pitcher Phil Maton from the San Diego Padres for international bonus pool money in 2019-20.

The Seattle Mariners acquired pitcher Matt Wisler from the San Diego Padres for cash.

The San Francisco Giants acquired outfielder Alex Dickerson from the San Diego Padres for pitcher Franklin Van Gurp.

The Toronto Blue Jays acquired outfielder Socrates Brito from the San Diego Padres for outfielder Rodrigo Orozco.

The San Diego Padres acquired pitcher Matt Wisler from the Cincinnati Reds for pitcher Diomar Lopez.

The Toronto Blue Jays acquired pitcher Clayton Richard and cash from the San Diego Padres for outfielder/infielder Connor Panas.

The Pittsburgh Pirates acquired pitcher Cristofer Melendez from the San Diego Padres for cash considerations.

The Chicago Cubs acquired pitcher Rowan Wick from the San Diego Padres for infielder Jason Vosler.

The Cleveland Indians acquired pitcher Walker Lockett from the San Diego Padres for pitcher Ignacio Feliz.

The Boston Red Sox acquired pitcher Colten Brewer from the San Diego Padres for infielder Esteban Quiroz.

The Atlanta Braves acquired catcher Raffy Lopez from the San Diego Padres for cash.

The Cleveland Indians acquired pitchers Brad Hand and Adam Cimber from the San Diego Padres for catcher Francisco Mejia.

The San Diego Padres acquired pitcher Phil Hughes, a competitive balance round B draft pick in 2018 (No. 74 overall) and cash from the Minnesota Twins for catcher Janigson Villalobos.

The San Diego Padres acquired catcher Brett Nicholas from the Texas Rangers for a player to be named later.

The Chicago White Sox acquired infielder Jose Rondon from the San Diego Padres for cash.

The Toronto Blue Jays acquired infielder Yangervis Solarte from the San Diego Padres for outfielder Edward Olivares and pitcher Jared Carkuff.

The San Diego Padres acquired shortstop Freddy Galvis from the Philadelphia Phillies for pitcher Enyel De Los Santos.

The Tampa Bay Rays acquired infielder Ryan Schimpf from the San Diego Padres for infielder Deion Tansel.

The San Diego Padres acquired infielder Chase Headley, pitcher Bryan Mitchell and cash from the New York Yankees for outfielder Jabari Blash.

The Kansas City Royals acquired pitchers Trevor Cahill, Brandon Maurer and Ryan Buchter from the San Diego Padres for pitchers Matt Strahm and Travis Wood, plus infielder Esteury Ruiz.

The San Diego Padres acquired outfielder Matt Szczur from the Chicago Cubs for pitcher Justin Hancock.

The Washington Nationals acquired catcher Derek Norris from the San Diego Padres for pitcher Pedro Avila.

The Miami Marlins acquired pitcher Luis Castillo from the San Diego Padres for pitcher Colin Rea.

The Atlanta Braves acquired outfielder Matt Kemp and cash from the San Diego Padres for outfielder/infielder Hector Olivera.

The Miami Marlins acquired pitchers Andrew Cashner, Colin Rea and Tayron Guerrero, and cash to the San Diego Padres for pitchers Jarred Cosart, Carter Capps and Luis Castillo, and outfielder/first baseman Josh Naylor.

The Toronto Blue Jays acquired outfielder Melvin Upton Jr. and cash from the San Diego Padres for pitcher Hansel Rodriguez.

The Boston Red Sox acquired pitcher Drew Pomeranz from the San Diego Padres for pitcher Anderson Espinoza.

The Miami Marlins acquired pitcher Fernando Rodney from the San Diego Padres for pitcher Chris Paddack.

The Chicago White Sox acquired pitcher James Shields and cash from the San Diego Padres for pitcher Erik Johnson and infielder Fernando Tatis Jr.

The New York Mets acquired first baseman James Loney from the San Diego Padres for cash.

The Seattle Mariners acquired pitcher Nick Vincent from the San Diego Padres for a player to be named later or cash considerations.

The Houston Astros acquired catcher Erik Kratz from the San Diego Padres for pitcher Dan Straily.

The Baltimore Orioles acquired pitcher Odrisamer Despaigne from the San Diego Padres for pitcher Jean Cosme.

The Milwaukee Brewers acquired outfielder Rymer Liriano from the San Diego Padres for pitcher Trevor Seidenberger.

The San Diego Padres acquired catcher Christian Bethancourt from the Atlanta Braves for pitcher Casey Kelly and catcher Ricardo Rodriguez.

The St. Louis Cardinals acquired infielder Jedd Gyorko and cash from the San Diego Padres for outfielder Jon Jay.

The Oakland Athletics acquired first baseman Yonder Alonso and pitcher Marc Rzepczynski from the San Diego Padres for pitchers Drew Pomeranz and Jose Torres, and a player to be named later.

The Boston Red Sox acquired pitcher Craig Kimbrel from the San Diego Padres for outfielder Manuel Margot, pitcher Logan Allen plus infielders Javier Guerra and Carlos Asuaje.

The Seattle Mariners acquired pitcher Joaquin Benoit from the San Diego Padres for pitcher Enyel De Los Santos and infielder Nelson Ward.

The San Diego Padres acquired infielder Jose Pirela from the New York Yankees for pitcher Ronald Herrera.

The Texas Rangers acquired outfielder Will Venable from the San Diego Padres for catcher Marcus Greene Jr. and a player to be named later (Jon Edwards - 08/21/2015).

The San Diego Padres acquired pitcher Marc Rzepczynski from the Cleveland Indians for outfielder Abraham Almonte.

The San Diego Padres acquired pitcher Craig Kimbrel and outfielder Melvin Upton Jr. from the Atlanta Braves for outfielders Cameron Maybin, Carlos Quentin and Jordan Paroubeck, pitcher Matt Wisler and a competitive balance round A draft pick in 2015.

The New York Mets acquired pitcher Alex Torres from the San Diego Padres for pitcher Cory Mazzoni and a player to be named later.

The Seattle Mariners acquired outfielder Seth Smith from the San Diego Padres for pitcher Brandon Maurer.

The San Diego Padres acquired pitcher Shawn Kelley from the New York Yankees for pitcher Johnny Barbato.

The San Diego Padres acquired third baseman Will Middlebrooks from the Boston Red Sox for catcher Ryan Hanigan.

The San Diego Padres acquired outfielder Justin Upton, pitcher Aaron Northcraft from the Atlanta Braves for pitcher Max Fried, infielder Jace Peterson, outfielder/infielder Dustin Peterson and outfielder Mallex Smith.

In a three-team trade, the San Diego Padres acquired outfielder Wil Myers, catcher Ryan Hanigan and pitchers Jose Castillo and Gerardo Reyes from the Tampa Bay Rays; Tampa Bay acquired outfielder Steven Souza and pitcher Travis Ott from the Washington Nationals, and catcher Rene Rivera, pitcher Burch Smith and first baseman/outfielder Jake Bauers from the Padres, and Washington acquired pitcher Joe Ross and a player to be named later from the Padres.

The San Diego Padres acquired catcher Derek Norris, pitcher Seth Streich and cash from the Oakland Athletics for pitchers Jesse Hahn and R.J. Alvarez.

The San Diego Padres acquired outfielder Matt Kemp, catcher Tim Federowicz and cash from the Los Angeles Dodgers for catcher Yasmani Grandal and pitchers Joe Wieland and Zach Eflin.

The Kansas City Royals acquired outfielder Reymond Fuentes from the San Diego Padres for pitcher Kyle Bartsch.