Pena is out of the lineup for Friday's game against the Guardians.
Pena went 2-for-4 with a double, a stolen base and a run scored in Saturday's win over the Angels.
Pena went 2-for-5 with a three-run home run Saturday against the Diamondbacks.
Pena is absent from the lineup for Thursday's game in Baltimore, Matt Kawahara of the Houston Chronicle reports.
Pena went 0-for-4 with a stolen base Saturday against the White Sox.
Pena went 2-for-4 with a solo home run in Tuesday's 3-2 win over the Rays.
Pena went 2-for-4 with two RBI on Monday against the Rangers.
Pena went 3-for-4 with a solo home run, a double and a stolen base in Tuesday's loss to the Athletics.
Pena went 1-for-4 with a solo home run in Sunday's loss to the Mariners.
Pena went 3-for-5 with three RBI and three runs scored Friday against the Twins.