The Angels transferred Rendon (hamstring) to the 60-day injured list Thursday, Sam Blum of The Athletic reports.
Rendon said Friday that he has a high-grade partial tear of his left hamstring, Jeff Fletcher of The Orange County Register reports.
The Angels placed Rendon on the 10-day injured list Sunday.
Rendon departed Saturday's game in Cincinnati with a hamstring injury, Rhett Bollinger of MLB.com reports.
Rendon went 3-for-5 with a double and two runs in Monday's 7-3 victory versus the Rays.
Rendon is not in the lineup for Wednesday's contest against the Rays.
Rendon is absent from the lineup for Wednesday's game in Miami, Erica Weston of Bally Sports West reports.
Rendon will start at third base and bat leadoff in Thursday's season opener versus the Orioles.
Angels manager Ron Washington said he's experimenting with Rendon batting leadoff in Wednesday's Cactus League game since the team doesn't have an ideal option, Rhett Bollinger of MLB.com reports.
Rendon (groin) will start at third base and bat cleanup in Sunday's Cactus League game against the Padres, Jeff Fletcher of The Orange County Register reports.