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| Year | Team | League | G | GS | W | L | CG | SHO | SV | IP | H | R | ER | HR | BB | K | ERA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2024 | NY Yankees | AL | 9 | 9 | 3 | 2 | 0 | 0 | 0 | 48.2 | 44 | 21 | 18 | 7 | 25 | 42 | 3.33 |
| 2023 | Chicago Cubs | NL | 27 | 25 | 10 | 9 | 1 | 1 | 0 | 136.2 | 120 | 68 | 60 | 9 | 52 | 119 | 3.95 |
| 2022 | Chicago Cubs | NL | 25 | 25 | 6 | 7 | 0 | 0 | 0 | 138.2 | 123 | 61 | 54 | 16 | 36 | 119 | 3.50 |
| Iowa | AAA | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2.2 | 7 | 5 | 5 | 0 | 1 | 2 | 16.88 | |
| 2021 | NY Mets | NL | 33 | 33 | 10 | 13 | 0 | 0 | 0 | 179 | 161 | 70 | 60 | 17 | 44 | 158 | 3.02 |
| 2020 | NYN-Injured | NL | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| 2019 | NY Mets | NL | 11 | 11 | 4 | 2 | 0 | 0 | 0 | 59.2 | 65 | 27 | 25 | 8 | 23 | 60 | 3.77 |
| Toronto | AL | 21 | 21 | 6 | 11 | 0 | 0 | 0 | 124.2 | 118 | 50 | 41 | 10 | 35 | 99 | 2.96 | |
| Total Tor/NYN | MLB | 32 | 32 | 10 | 13 | 0 | 0 | 0 | 184.1 | 183 | 77 | 66 | 18 | 58 | 159 | 3.22 | |
| 2018 | Toronto | AL | 19 | 19 | 4 | 9 | 0 | 0 | 0 | 102.1 | 115 | 68 | 63 | 9 | 36 | 77 | 5.54 |
| Dunedin | A | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 4.1 | 1 | 2 | 2 | 1 | 4 | 3 | 4.15 | |
| 2017 | Toronto | AL | 33 | 33 | 13 | 9 | 2 | 0 | 0 | 201 | 201 | 82 | 69 | 21 | 62 | 164 | 3.09 |
| 2016 | Toronto | AL | 32 | 32 | 9 | 10 | 0 | 0 | 0 | 204 | 209 | 104 | 99 | 21 | 54 | 166 | 4.37 |
| 2015 | Toronto | AL | 4 | 4 | 4 | 0 | 0 | 0 | 0 | 27 | 20 | 5 | 5 | 2 | 6 | 18 | 1.67 |
| Buffalo | AAA | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 3 | 8 | 4 | 4 | 0 | 4 | 5 | 12.00 | |
| Lansing | A | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 4.2 | 0 | 0 | 0 | 0 | 1 | 7 | 0.00 | |
| 2014 | Toronto | AL | 26 | 20 | 11 | 6 | 1 | 1 | 1 | 130.2 | 125 | 56 | 53 | 7 | 28 | 111 | 3.65 |
| Buffalo | AAA | 7 | 7 | 2 | 4 | 1 | 0 | 0 | 35.2 | 32 | 14 | 12 | 1 | 9 | 45 | 3.03 | |
| 2013 | New Hampshire | AA | 20 | 20 | 9 | 5 | 0 | 0 | 0 | 111.2 | 99 | 48 | 41 | 13 | 27 | 129 | 3.30 |
| 2012 | New Hampshire | AA | 8 | 0 | 2 | 0 | 0 | 0 | 0 | 8 | 8 | 3 | 3 | 1 | 6 | 8 | 3.38 |
| Vancouver | A | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 11.1 | 8 | 5 | 4 | 0 | 3 | 15 | 3.18 | |
| Duke | NCAA | 14 | 14 | 6 | 5 | 1 | 0 | 0 | 98 | 83 | 31 | 26 | 5 | 26 | 136 | 2.39 | |
| 2011 | Duke | NCAA | 17 | 8 | 3 | 4 | 0 | 0 | 4 | 64.1 | 59 | 21 | 20 | - | 21 | 90 | 2.80 |
| 2010 | Duke | NCAA | 17 | 5 | 6 | 4 | 1 | 0 | 3 | 57.2 | 57 | 36 | 34 | - | 25 | 64 | 5.30 |
| MLB | Total | MLB | 240 | 232 | 80 | 78 | 4 | 2 | 1 | 1352.1 | 1301 | 612 | 547 | 127 | 401 | 1133 | 3.64 |
| NL | Total | NL | 96 | 94 | 30 | 31 | 1 | 1 | 0 | 514 | 469 | 226 | 199 | 50 | 155 | 456 | 3.48 |
| AL | Total | AL | 144 | 138 | 50 | 47 | 3 | 1 | 1 | 838.1 | 832 | 386 | 348 | 77 | 246 | 677 | 3.74 |
| AAA | Total | AAA | 8 | 8 | 2 | 5 | 1 | 0 | 0 | 38.2 | 40 | 18 | 16 | 1 | 13 | 50 | 3.72 |
| AA | Total | AA | 28 | 20 | 11 | 5 | 0 | 0 | 0 | 119.2 | 107 | 51 | 44 | 14 | 33 | 137 | 3.31 |
| A | Total | A | 9 | 2 | 1 | 1 | 0 | 0 | 0 | 20.1 | 9 | 7 | 6 | 1 | 8 | 25 | 2.66 |
| NCAA | Total | NCAA | 48 | 27 | 15 | 13 | 2 | 0 | 7 | 220 | 199 | 88 | 80 | 5 | 72 | 290 | 3.27 |
