Santiago has been suspended for 80 games after testing positive for exogenous testosterone, in violation of MLB's Joint Drug Prevention and Treatment program, Mark Feinsand of MLB.com reports.

The Mariners reinstated Santiago to the active roster Tuesday after he completed his 10-game suspension.

Santiago's 10-game suspension was upheld Thursday, Jeff Passan of ESPN.com reports.

Santiago allowed one run on two hits and a walk while striking out one over three innings Sunday against the Angels. He did not factor into the decision.

Seattle manager Scott Servais said Santiago will start Sunday's game against the Angels, Ryan Divish of The Seattle Times reports.

Santiago, who's currently appealing his 10-game suspension for allegedly having a foreign substance on his glove, fired a scoreless eighth inning in an extra-inning win over the Rangers on Friday, allowing one hit and recording three strikeouts.

Santiago was handed a 10-game suspension Tuesday for having a foreign substance on his glove during Sunday's game against the White Sox, Jeff Passan of ESPN.com reports. He will appeal and remain on the 26-man roster until the league makes a final decision.

Santiago was ejected in the bottom of the fifth inning during Sunday's game against the White Sox because of a foreign substance on his glove, Jeff Passan of ESPN.com reports. He allowed one run on three hits and two walks before departing.

Santiago (1-1) earned the win Thursday against the Rays after tossing a scoreless inning, striking out the three batters he faced.

Santiago (0-1) was handed the loss Friday against the Angels, allowing an earned run on two hits and a walk while recording five strikeouts over three innings.