Descalso opted out of his Triple-A St. Paul contract Tuesday, Brandon Warne of Access Twins reports.
Descalso signed a minor-league contract with the Twins on Thursday, Brandon Warne of Access Twins reports.
Descalso's (ankle) $3.5 million team option was declined by the Cubs on Saturday.
The Cubs placed Descalso on the 45-day injured list Wednesday with a left ankle sprain, Bruce Levine of 670TheScore.com reports.
Descalso will be a part of the Cubs' 60-man player pool this season and will head to Wrigley Field for summer camp.
Descalso is likely to serve as a reserve infielder for the Cubs this year rather than being in the mix to start at second base, Jordan Bastian of MLB.com reports.
Descalso will battle the likes of David Bote, Nico Hoerner and the newly signed Jason Kipnis for playing time at second base to begin the year, Jordan Bastian of MLB.com reports.
Descalso (ankle) was activated off the 10-day injured list Sunday.
Descalso (ankle) is 2-for-17 with two home runs through seven rehab games with Triple-A Iowa.
Descalso (ankle) will begin a rehab assignment with Triple-A Iowa on Saturday, Jordan Bastian of MLB.com reports.