Skenes (1-0) earned the win over the Cubs on Friday, issuing just one walk while striking out 11 over six hitless innings.
Skenes' contract was purchased from Triple-A Indianapolis ahead of his big-league debut Saturday against the Cubs.
The Pirates announced that Skenes will be promoted from Triple-A Indianapolis to start Saturday against the Cubs at PNC Park.
Pirates manager Derek Shelton said Monday that Skenes is scheduled to make another start with Triple-A Indianapolis this week, Alex Stumpf of MLB.com reports.
Skenes' next start will come Sunday at Triple-A Indianapolis against Buffalo.
Skenes allowed four hits and one walk while striking out seven across six scoreless innings Tuesday in an appearance with Triple-A Indianapolis.
Pirates general manager Ben Cherington said Monday that Skenes will begin the season with Triple-A Indianapolis, Jason Mackey of the Pittsburgh Post-Gazette reports.
The Pirates reassigned Skenes to minor-league camp Sunday.
Skenes (illness) is scheduled to start Thursday in the Pirates' Spring Breakout game against the Orioles, Kevin Gorman of TribLive.com reports.
Skenes will not play in Saturday's Grapefruit League game against the Tigers due to an illness, Jason Mackey of the Pittsburgh Post-Gazette reports.