Spiers will start Tuesday's game in Cleveland.
Spiers is likely to enter the Reds' rotation in place of the injured Julian Aguiar (shoulder), Charlie Goldsmith of The Cincinnati Enquirer reports.
Spiers tossed two innings of relief and gave up three earned runs on three hits and no walks while striking out three Friday in the Reds' 14-0 loss to the Brewers in the second game of a doubleheader.
Spiers threw four scoreless innings out of the bullpen in Sunday's 4-3 loss to the Pirates, allowing three hits without a walk. He struck out one batter.
Spiers is slated to work in bulk relief behind opening pitcher Emilio Pagan in Wednesday's game against the Cardinals, Charlie Goldsmith of The Cincinnati Enquirer reports.
Spiers (4-3) took the loss Sunday against the Giants, allowing three earned runs on five hits and zero walks in 5.2 innings. He struck out five.
The Reds activated Spiers (shoulder) from the 15-day injured list Monday.
Spiers (shoulder) is scheduled to start Monday against the Cubs,
Spiers (shoulder) had a clean MRI on Saturday, and he is likely to miss only one start, C. Trent Rosecrans of The Athletic reports.
The Reds placed Spiers on the 15-day injured list due to a right shoulder impingement Saturday.