Loftin was optioned to Triple-A Omaha by the Royals on Thursday.
Loftin went 2-for-3 with a walk, three RBI and a run scored in Saturday's 11-7 win over the Mets.
Loftin will start at designated hitter and bat eighth in Saturday's game against the Twins.
Manager Matt Quatraro informed Loftin that he made the Royals' Opening Day roster, Anne Rogers of MLB.com reports Saturday.
Loftin is preparing to fill a utility role in 2024, Anne Rogers of MLB.com reports.
Loftin went 2-for-3 with two RBI and his first MLB stolen base in Tuesday's 7-6 win over the Guardians.
Loftin will start at first base and bat eighth in Tuesday's game against the White Sox.