The Cubs transferred Little (lat) to the 60-day injured list Monday, Ryan Herrera of CHGO Sports reports.
Manager Craig Counsell said Saturday that Little (lat) is likely out for the rest of the season, Mike McGraw of the Chicago Daily Herald reports.
Little will undergo an MRI on his injured left shoulder Friday, Bruce Levine of 670TheScore.com reports.
The Cubs placed Little on the 15-day injured list Saturday with a left shoulder strain, Sahadev Sharma of The Athletic reports.
Little (3-1) tossed a scoreless inning of relief to earn the win in Saturday's 5-3 victory over the Brewers. He allowed two hits and struck out one.
Little was called up from Triple-A Iowa on Sunday, Taylor McGregor of Marquee Sports Network reports.
The Cubs optioned Little to Triple-A Iowa on Saturday, Andy Martinez of Marquee Sports Network reports.
The Cubs recalled Little from Triple-A Iowa on Wednesday, Ryan Herrera of MLB.com reports.
The Cubs optioned Little to Triple-A Iowa on Sunday, Meghan Montemurro of the Chicago Tribune reports.
Little allowed five runs on three hits and a walk while retiring just two batters in Saturday's 17-0 loss to the Red Sox.