Pilkington was outrighted to Triple-A Reno on Thursday, per the MLB transaction log.
Pilkington was designated for assignment by the Diamondbacks on Friday.
Arizona acquired Pilkington from Cleveland on Monday in exchange for cash considerations.
The Guardians designated Pilkington for assignment Wednesday, Joe Noga of The Cleveland Plain Dealer reports.
The Guardians recalled Pilkington from Triple-a Columbus on Tuesday, Ryan Lewis of the Akron Beacon Journal reports.
The Guardians optioned Pilkington to Triple-A Columbus following Tuesday's doubleheader versus the Tigers.
The Guardians recalled Pilkington from Triple-A Columbus on Tuesday, Mandy Bell of MLB.com reports.
Pilkington was optioned to Triple-A Columbus by the Guardians on Friday.
Pilkington has allowed five earned runs, 10 hits and four walks while striking out eight over 6.1 innings across three Cactus League appearances.
Pilkington struck out four over 3.1 innings and allowed four earned runs on three hits and three walks in his most recent start Friday for Triple-A Columbus.