Cantillo is no longer starting Wednesday's game against the Reds and instead will pitch in Friday's series opener versus the Astros, Zack Meisel of The Athletic reports.
Cantillo is scheduled to start Saturday's game against the Rays in Cleveland.
The Guardians recalled Cantillo from Triple-A Columbus on Monday.
Cantillo is expected to be called up from Triple-A Columbus and start Monday's contest against the White Sox, Joe Noga of The Cleveland Plain Dealer reports.
Cantillo didn't allow a baserunner over 1.2 scoreless innings and struck out one in a 4-3 loss to the Royals in Game 1 of Monday's doubleheader.
The Guardians recalled Cantillo from Triple-A Columbus prior to Monday's doubleheader with the Royals.
The Guardians will designate Cantillo as the 27th man for Monday's doubleheader against the Royals, Zack Meisel of The Athletic reports.
The Guardians optioned Cantillo to Triple-A Columbus on Thursday.
Cantillo (0-3) took the loss Wednesday as the Guardians fell 8-1 to the Yankees, surrendering seven runs on six hits and three walks over four innings. He struck out five.
The Guardians recalled Cantillo from Triple-A Columbus in advance of his start Wednesday against the Yankees.