De Los Santos signed a one-year contract with the Padres on Thursday to avoid arbitration.

De Los Santos (5-2) struck out the only batter he faced and earned the win in Game 2 of Friday's doubleheader versus the Tigers.

De Los Santos (3-1) struck out one without giving up a hit or a walk in a scoreless inning to earn the extra-inning win over the Athletics on Tuesday.

De Los Santos (2-1) allowed four runs on two hits and two walks without recording an out to take the loss Tuesday versus the Red Sox.

De Los Santos (2-0) earned the win Monday over the Yankees, recording two outs without allowing a baserunner.

De Los Santos was reinstated from the paternity list Friday, Tom Withers of the Associated Press reports.

The Guardians placed De Los Santos on the paternity leave list Tuesday, Mandy Bell of MLB.com reports.

De Los Santos is available to pitch Wednesday versus Team Mexico, Paul Hoynes of The Cleveland Plain Dealer reports.

De Los Santos is dealing with a hamstring injury and may not be ready for Opening Day, Paul Hoynes of The Cleveland Plain Dealer reports.

De Los Santos (5-0) struck out two in a perfect inning to earn the win Thursday over the Rays.