Coulombe has allowed one run on four hits over three innings in Grapefruit League play this spring.
Coulombe signed a one-year contract with the Orioles on Monday that includes a club option for 2025.
Coulombe (4-1) pitched 1.2 perfect innings to earn the win Tuesday over the White Sox.
Coulombe (biceps) was activated from the 15-day injured list Thursday.
Coulombe (biceps) began a rehab assignment with Triple-A Norfolk on Tuesday and struck out two batters over a scoreless inning.
Coulombe was placed on the 15-day injured list Thursday with left biceps tendinitis.
Coulombe (3-1) allowed one hit and struck out three without walking a batter over 2.1 scoreless innings to earn the win Wednesday over the Dodgers.
Coulombe picked up the save in Sunday's 5-4 victory over the Marlins. He allowed a run on two hits over two-thirds of an inning.
Coulombe was reinstated from the bereavement list Tuesday, Andy Kostka of TheBaltimoreBanner.com reports.
The Orioles placed Coulombe on the bereavement list Saturday.