Santander rejected the Orioles' $21.05 million qualifying offer Tuesday, Rich Dubroff of BaltimoreBaseball.com reports.
The Orioles extended Santander a $21.05 million qualifying offer Monday, Jake Rill of MLB.com reports.
Santander is absent from Sunday's lineup against Minnesota.
Santander went 1-for-3 with a two-run home run and a walk in Friday's 7-1 win over the Tigers.
Santander went 1-for-3 with a two-run homer, two walks and a second run scored in Thursday's 5-3 win over the Giants.
Santander went 2-for-4 with a double and a two-run homer in Saturday's loss to the Rockies.
Santander is not in Sunday's lineup against Boston.
Santander went 2-for-5 with two home runs and three RBI in Wednesday's 7-3 win over the Blue Jays.
Santander went 1-for-4 with a solo home run in Thursday's 10-3 loss to the Guardians.
Santander went 2-for-5 with a solo home run in Thursday's 7-6 extra-inning win over the Marlins.