Santander was removed from Wednesday's game against the Blue Jays due to a bruised knee, Jake Rill of MLB.com reports.
Santander went 1-for-3 with a solo home run and a walk in Wednesday's 7-6 extra-innings win over the Nationals.
Santander is out of the lineup for Wednesday's game against the Yankees.
Santander went 3-for-5 with three doubles, two RBI and one run scored in Saturday's 9-7 win over the Royals.
Santander went 1-for-4 with a solo home run in Wednesday's 4-2 win over the Twins.
Santander is not in the lineup for Monday's game against the Twins, Roch Kubatko of MASNSports.com reports.
Santander went 1-for-4 with a two-run home run in Thursday's 9-4 win over the Red Sox.
Santander went 2-for-4 with a three -run home run and an additional run scored during Saturday's 13-4 win against the Angels.
Santander has gone 2-for-14 over his first five Grapefruit League games.
Santander signed a one-year, $11.7 million contract with the Orioles on Thursday, avoiding arbitration, Robert Murray of FanSided.com reports.