Hughes recorded four tackles and two sacks in Sunday's 23-20 loss to the Bears in Week 3.
Hughes had three tackles, two sacks, an interception and forced a fumble in Sunday's 20-20 tie with the Colts in Week 1.
Hughes started at defensive end and saw his first action of the preseason in Thursday's game against the 49ers, Brooks Kubena of the Houston Chronicle reports.
The Texans signed Hughes on Tuesday, NFL reporter Jordan Schultz reports.
General manager Brandon Beane said this week that while he expects Hughes -- an unrestricted free agent -- to explore the market, he's very open to having the veteran return to the team, the Bills' official site reports.
Coach Sean McDermott said Friday on WGR 550 Radio that Hughes (foot) is expected to practice fully Friday and play Sunday against the Panthers, Chris Jenkins of the Bills' official site reports.
Hughes had just one tackle in Monday's 14-10 loss to the Patriots while playing 51 percent of the defensive snaps.
Hughes (calf) was activated off NFI list Tuesday, the Bills' official site reports.
Hughes (coach's decision) is inactive for Sunday's game versus the Dolphins.