Mixon has signed a three-year contract extension with the Texans, Adam Schefter of ESPN reports.
The Bengals are slated to trade Mixon to the Texans, Ian Rapoport of NFL Network reports.
Mixon is a potential cap casualty this offseason, though it won't be surprising if he's back with the Bengals instead, ESPN's Jeremy Fowler reports.
Mixon rushed 14 times for 111 yards and a touchdown while catching one of two targets for a six-yard touchdown in Sunday's 31-14 win over the Browns. He finishes the season with 1,034 yards and nine touchdowns on 257 rushing attempts, along with 52 catches on 63 targets for 376 yards and three touchdowns.
Mixon (illness) doesn't carry an injury designation for Sunday's game against the Browns.
Mixon was added to the Bengals' Week 18 injury report after sitting out Thursday's practice with an illness.
Mixon ran for 47 yards and one touchdown on 10 carries in the 27-24 overtime win against the Vikings on Saturday while adding three catches for 14 yards on three targets.
Mixon rushed 21 times for 79 yards and a touchdown and brought in three of four targets for 46 yards in the Bengals' 34-14 win over the Colts on Sunday.
Mixon rushed 11 times for 46 yards and a touchdown and brought in two of three targets for minus-1 yard in the Bengals' 30-27 loss to the Texans on Sunday.
Mixon (chest) is listed as active for Sunday night's game against the Bills.