The Texans placed Diggs (knee) on injured reserve Tuesday.
Texans head coach DeMeco Ryans said Tuesday that Diggs (knee) has been diagnosed with a season-ending right ACL tear, Jonathan M. Alexander of the Houston Chronicle reports.
Diggs (knee) was listed as a non-participant in Monday's estimated practice, Aaron Wilson of KPRC 2 Houston reports.
Diggs was forced out of Sunday's game against the Colts with a knee injury.
Diggs caught five of seven targets for 23 yards in Sunday's 24-22 loss to the Packers.
Diggs caught six of seven targets for 77 yards and a touchdown in Sunday's 41-21 win over the Patriots.
Diggs is poised to lead Houston's receiving corps for the next four weeks, starting with Sunday's game against the Patriots, as the Texans placed Nico Collins (hamstring) on injured reserve Wednesday.
Diggs caught six of eight targets for 82 yards in Sunday's 23-20 win over the Bills.
Diggs caught 10 of 12 targets for 94 yards in Sunday's 34-7 loss to the Vikings.
Diggs caught all six of his targets for 33 yards and two touchdowns in Sunday's 29-27 win over the Colts. He added six rushing yards on one carry.