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| Year | Team | League | G | GS | Rush | Yds | Avg | Lg | TD | Rec | Yds | Lg | TD | Fum |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2021 | Jacksonville | NFL | 12 | 2 | 72 | 253 | 3.5 | 18 | 1 | 12 | 65 | 9 | 0 | - |
| 2020 | Seattle | NFL | 10 | 1 | 81 | 356 | 4.4 | 50 | 4 | 16 | 93 | 18 | 0 | 1 |
| 2019 | Houston | NFL | 16 | 14 | 245 | 1070 | 4.4 | 58 | 6 | 10 | 42 | 14 | 0 | 4 |
| 2018 | Jacksonville | NFL | 8 | 2 | 58 | 189 | 3.3 | 19 | 0 | 4 | 4 | 6 | 0 | 1 |
| Cleveland | NFL | 6 | 5 | 114 | 382 | 3.4 | 22 | 5 | 6 | 29 | 9 | 0 | 1 | |
| Total Cle/Jax | NFL | 14 | 7 | 172 | 571 | 3.3 | 22 | 5 | 10 | 33 | 9 | 0 | 2 | |
| 2017 | San Francisco | NFL | 16 | 16 | 240 | 940 | 3.9 | 61 | 8 | 59 | 350 | 18 | 0 | 2 |
| 2016 | San Francisco | NFL | 13 | 13 | 217 | 988 | 4.6 | 47 | 6 | 27 | 163 | 19 | 3 | 5 |
| 2015 | San Francisco | NFL | 7 | 7 | 115 | 470 | 4.1 | 22 | 3 | 11 | 53 | 11 | 0 | 1 |
| 2014 | San Francisco | NFL | 14 | 0 | 83 | 333 | 4.0 | 28 | 4 | 12 | 68 | 16 | 0 | 1 |
| 2013 | Ohio State | NCAA | 11 | - | 208 | 1521 | 7.3 | 55 | 15 | 16 | 147 | 25 | 3 | - |
| 2012 | Ohio State | NCAA | 10 | - | 185 | 970 | 5.2 | 29 | 16 | 8 | 51 | 14 | 1 | - |
| 2011 | Ohio State | NCAA | 13 | - | 106 | 566 | 5.3 | 63 | 6 | 10 | 73 | 12 | 0 | - |
| 2010 | Ohio State | NCAA | 7 | - | 24 | 141 | 5.9 | 16 | 0 | 0 | 0 | 0 | 0 | - |
| NFL | Total | NFL | 102 | 60 | 1225 | 4981 | 4.1 | 61 | 37 | 157 | 867 | 19 | 3 | 18 |
| NCAA | Total | NCAA | 41 | - | 523 | 3198 | 6.1 | 63 | 37 | 34 | 271 | 25 | 4 | - |
