Bethune (knee) is active ahead of Monday night's matchup against the Lions, Lindsey Pallares of the 49ers' official site reports.
Bethune (knee) was activated from the injured reserve list Monday.
Bethune (knee) was designated to return from injured reserve Friday, Aaron Wilson of KPRC 2 Houston reports.
Coach Kyle Shanahan said Tuesday that Bethune sustained a sprained MCL during Sunday's game versus the Seahawks and will be out for a while, Eric Branch of the San Francisco Chronicle reports.
Bethune (knee) has been ruled out for the rest of Sunday's game against the Seahawks, Nick Wagoner of ESPN.com reports.
Bethune (knee) is questionable to return to Sunday's game against the Seahawks.