Brown posted eight tackles (six solo), including one for loss, in a 36-24 Week 6 win over Seattle on Thursday.
Brown (ankle) will play Thursday against the Seahawks.
Brown (ankle) has left Sunday's game against the Cardinals, Nick Wagoner of ESPN.com reports.
Brown recorded 35 tackles (22 solo) with two interceptions over 15 games with San Francisco in 2023.
Brown (knee) was a full participant at practice Tuesday, Nick Wagoner of ESPN.com reports.
Brown (knee) is inactive for Sunday's Week 17 game against the Commanders.
Brown is expected to start at strong safety moving forward after Talanoa Hufanga suffered a torn ACL in the 49ers' win over the Buccaneers on Sunday, Nick Wagoner reports.