The Giants placed Layne (knee) on injured reserve Saturday, Dan Salomone of the Giants' official site reports.
Layne (knee) has been ruled out ahead of Sunday's matchup against the Colts, Ralph Vacchiano of Fox Sports reports.
Layne's recent surgery to repair a torn ACL was a success according to his Instagram account, Kris Rhim of ESPN.com reports.
Layne (knee) was placed on injured reserve by the Chargers on Wednesday, Aaron Wilson of KPRC 2 Houston reports.
Layne (knee) suffered a torn ACL in Monday's 20-17 loss to the Cowboys, Daniel Popper of The Athletic reports.