Mitchell had four carries for seven yards and a touchdown Sunday in the 49ers' 34-31 win over the Lions in the NFC Championship Game.
Mitchell rushed for 52 yards and a touchdown on 14 attempts while catching both of his targets for 15 yards in Sunday's 21-20 loss to the Rams.
Mitchell (illness) doesn't have a game designation for Sunday against the Rams, Eric Branch of the San Francisco Chronicle reports.
Mitchell profiles as the next man up to lead the San Francisco backfield in Sunday's game against the Rams with Christian McCaffrey (calf) having been ruled out for Week 18, Nick Wagoner of ESPN.com reports.
Mitchell racked up 17 carries for 80 yards and one touchdown during Sunday's 27-10 win at Washington.
San Francisco head coach Kyle Shanahan said Tuesday that Mitchell (knee) is expected to be "full go" in Week 17, Matt Barrows of The Athletic reports.
Mitchell (knee) is listed as inactive Monday versus the Ravens, Lindsey Pallares of the 49ers' official site reports.
Mitchell (knee) is listed as questionable for Monday's game against the Ravens, Cam Inman of The San Jose Mercury News reports.
Mitchell (knee) was a non-participant at Thursday's practice, Cam Inman of The San Jose Mercury News reports.
Mitchell (knee) has been ruled out for Sunday's game against Arizona, Nick Wagoner of ESPN.com reports.