Rousseau had two tackles, one pass defensed and half a sack during Buffalo's 20-17 win over the Chiefs on Sunday.
Rousseau (foot) does not carry an injury designation ahead of Sunday's game versus the Giants.
Coach Sean McDermott said Friday that Rousseau (foot) is ruled out for Sunday's game against the Jaguars, Katherine Fitzgerald of The Buffalo News reports.
Rousseau (foot) did not participate at practice Wednesday, Chris Brown of the Bills' official site reports.
Rousseau finished the 2022 regular season with 37 tackles, eight sacks, four passes defended and one forced fumble over 13 games.
Rousseau (ankle) was a full participant in practice Monday.
Rousseau (ankle) has been ruled for Thursday's contest versus the Lions, Alaina Getzenberg of ESPN.com reports.
Rousseau (ankle) has been ruled out for Sunday's contest against the Browns, Alaina Getzenberg of ESPN.com reports.
Rousseau missed practice Wednesday due to an ankle injury.
Rousseau (ankle) has been ruled out for Sunday's game against the Vikings, Maddy Glab of the Bills' official site reports.