Melifonwu recorded 33 tackles, 3.0 sacks, eight pass breakups, two interceptions and one forced fumble over 17 regular-season games in 2023.
Melifonwu had three solo tackles and an interception in Saturday's 20-19 loss to the Cowboys.
Melifonwu totaled five tackles with two sacks and two pass breakups with one interception during Sunday's win over the Vikings.
Melifonwu (hand) is active Sunday against the Bears.
Melifonwu will start Sunday against the Falcons, Kyle Meinke of MLive.com reports.
Melifonwu stood out at safety during recent minicamp practices, John Maakaron of Sports Illustrated reports.
Melifonwu (ankle) was listed as a full participant on the Lions' practice report Wednesday.
Melifonwu (ankle) is listed as inactive for Sunday's game against the Bears.
Melifonwu (ankle) has been ruled out for Sunday's game against the Packers, Tim Twentyman of the Lions' official site reports.
Melifonwu (ankle) has been ruled out of Sunday's game against the Dolphins, Tim Twentyman of the Lions' official site reports.