The Lions placed Melifonwu (undisclosed) on injured reserve Tuesday.

The Lions activated Melifonwu (ankle) from injured reserve Monday.

Head coach Dan Campell stated Monday that Melifonwu (ankle) suffered a setback, and 'he won't be ready for a while," Nolan Bianchi of The Detroit News reports.

Melifonwu (ankle) has been ruled out for Sunday's game against the Jaguars.

Melifonwu (ankle) was placed on injured reserve Saturday, Justin Rogers of DetroitFootball.net reports.

Melifonwu (ankle) is ruled out for Sunday's game against Arizona.

Melifonwu (ankle) has been ruled out ahead of Sunday's matchup with the Buccaneers.

Melifonwu (ankle) did not participate in Wednesday's practice session.

Melifonwu (ankle) will be inactive for Sunday's matchup with the Rams.

Melifonwu (ankle) is doubtful for Detroit's season opener against the Rams after logging limited practices all week, Eric Woodyard of ESPN.com reports.