Fries (lower leg) was placed on injured reserve Monday.
Fries will have surgery Sunday to repair a fractured tibia suffered in the team's Week 5 loss to the Jaguars, Adam Schefter of ESPN reports.
Head coach Shane Steichen said after Sunday's 37-34 loss to the Jaguars that Fries will undergo a procedure for his injured tibia, Kevin Bowen of 107.5 The Fan Indianapolis reports.
Fries exited Sunday's game against the Jaguars with a right leg injury and will not return, James Boyd of The Athletic reports.
Fries has left Sunday's game against the Ravens with cramps, Nate Atkins of The Indianapolis Star reports.
Fries (calf) didn't participate in practice Wednesday, George Bremer of The Anderson Herald Bulletin reports.
The Colts selected Fries in the seventh round of the 2021 NFL Draft, 248th overall.