Carolina placed Brown (knee) on injured reserve Tuesday, Darin Gantt of the Panthers' official site reports.
Brown (knee) is feared to have suffered potentially a season-ending meniscus injury during Sunday's 47-10 loss to the Saints, Tom Pelissero of NFL Network reports.
Brown has agreed to a four-year contract extension with the Panthers, Adam Schefter of ESPN reports.
Brown finished the regular season with 103 tackles (57 solo), two sacks and an interception in 17 games.
Brown finished Sunday's 26-0 loss to the Jaguars with eight tackles (three solo).
Brown logged nine total tackles (three solo) in Sunday's 33-30 loss to the Packers.
Brown finished with 10 tackles (nine solo) in the Panthers' 16-13 loss to the Bears on Thursday.
Brown (knee) is active for Sunday's game against Miami.
Brown (knee) is listed as questionable for Sunday's game at the Dolphins.
Brown accumulated seven tackles (four solo) in the 20-17 loss to New Orlean's in Week 2.