The Colts placed Dulin (knee) on injured reserve Thursday.
Dulin suffered a torn ACL during Wednesday's practice, Adam Schefter of ESPN reports.
Dulin agreed Wednesday with the Colts on a two-year, $7.2 million contract, Matt Adams of Fox 59 Indianapolis reports.
Dulin was not targeted in the passing game while playing 14 snaps on offense during Sunday's 32-31 defeat to the Texans.
Dulin doesn't have an injury designation for Sunday's matchup against the Texans.
Dulin (concussion) was a full participant during Wednesday's practice.
Dulin (concussion) has been ruled out for Sunday's game against the Giants.
Dulin (concussion) is not practicing Thursday, Nate Atkins of The Indianapolis Star reports.
Dulin (concussion) was listed as a non-participant in Wednesday's estimated practice report.
Dulin will not return after suffering a concussion during the second quarter of Monday's game against the Chargers, Zak Keefer of The Athletic reports.