Odum (knee) has been ruled out ahead of Sunday's matchup against the Bears, Cam Inman of The San Jose Mercury News reports.
David Lombardi of The Athletic relays that Odum's performance in training camp is earning him a bigger role in the 49ers' defense, and the 30-year-old is currently listed on as the starting strong safety on San Francisco's depth chart.
Odum is set to sign a two-year contract extension, which could be worth up to $10 million, with the 49ers, Tom Pelissero of NFL Network reports.
The 49ers activated Odum (biceps) from injured reserve Saturday and he's set to play in the team's NFC divisional-round game against the Packers, Jennifer Lee Chan of NBC Sports Bay Area reports.
The 49ers designated Odum (biceps) to return from injured reserve Tuesday.
The 49ers placed Odum (biceps) on their injured reserve list Monday.
Odum (biceps) suffered a torn biceps in Thursday's 31-13 win over the Seahawks and is expected to face a recovery timeline of two-to-four months, Tom Pelissero of NFL Network reports.
Odum (quadricep) was a full participant in Thursday's practice.
Odum is questionable to return to Sunday's game against the Browns due to a thigh injury, Eric Branch of the San Francisco Chronicle reports.
Odum agreed to a three-year, $10.95 million contract with the 49ers on Friday, Ian Rapoport of NFL Network reports.