Milano (leg) doesn't have a rehab timeline, though Bills GM Brandon Beane said Tuesday that the linebacker is "probably closer to being through rehab" than cornerback Tre'Davious White (Achilles), Katherine Fitzgerald of The Buffalo News reports.

Coach Sean McDermott said Friday he doesn't believe Milano (leg) has a chance to return from IR this season, Joe Buscaglia of The Athletic reports.

The Bills placed Milano (leg) on injured reserve Wednesday.

Milano has been diagnosed with a fractured leg and is also feared to have suffered a season-ending knee injury in Sunday's 25-20 loss to the Jaguars, Ian Rapoport of NFL Network reports.

Milano (knee), who won't return to Sunday's game against the Jaguars, had a full cast on his leg from his shin to his thigh after being carted off the field, Ian Rapoport of NFL Network reports.

Milano suffered a knee injury in the first quarter of Sunday's game against the Jaguars in London and won't return. He recorded three tackles prior to departing.

Milano recorded four tackles and an interception in Sunday's 38-10 win versus Las Vegas.

Milano recorded eight tackles (three solo) while also intercepting a pass and deflecting another in Monday's 22-16 loss to the Jets.

Milano missed practice Friday due to general soreness, Alec White and Maddy Glab of the Bills' official site report.

Milano signed a two-year contract extension Sunday, Adam Schefter of ESPN reports.