McCaffrey (knee) said Monday he's "definitely close" to 100 percent healthy and could have played had the 49ers qualified for the playoffs, Nick Wagoner of ESPN.com reports.

The 49ers placed McCaffrey (knee) on injured reserve Tuesday.

The 49ers placed McCaffrey (knee) on injured reserve Monday, Ian Rapoport of NFL Network reports.

McCaffrey (Achilles) doesn't have an injury designation for Sunday's game against Seattle, Cam Inman of The San Jose Mercury News reports.

Coach Kyle Shanahan said McCaffrey (Achilles) will be a limited practice participant Wednesday, Nick Wagoner of ESPN.com reports.

McCaffrey (Achilles) rushed 13 times for 39 yards and caught six of seven targets for 68 yards in Sunday's 23-20 win over Tampa Bay.

McCaffrey (Achilles) is listed as active Sunday at Tampa Bay, Lindsey Pallares of the 49ers' official site reports.

McCaffrey (Achilles) remains listed as questionable for Sunday's game against the Buccaneers, but he's on track to play and expressed confidence that he's take on his usual workload in his season debut, Mike Garafolo of NFL Network reports.

McCaffrey (Achilles) was activated off injured reserve Saturday, Adam Schefter of ESPN reports.

McCaffrey (Achilles) is listed as questionable for Sunday's game at Tampa Bay, with coach Kyle Shanahan saying Friday that the running back will play, Eric Branch of the San Francisco Chronicle reports.