Adam Schefter of ESPN reports that McCaffrey (Achilles/calf) will be placed on injured reserve Saturday.

The 49ers may place McCaffrey (calf/Achilles) on injured reserve Saturday, Ian Rapoport of NFL Network reports.

McCaffrey has been ruled out for Sunday's game against the Vikings. The 49ers are considering playing him on injured reserve, which would sideline him this week plus three more games, Tom Pelissero of NFL Network reports.

McCaffrey (Achilles) is not present at the portion of Friday's practice open to the media, Nick Wagoner of ESPN.com reports.

49ers GM John Lynch said Friday morning that he doesn't know if McCaffrey (Achilles) will play Sunday at the Vikings, Cam Inman of The San Jose Mercury News reports.

McCaffrey (calf/Achilles) remained limited at Thursday's practice, Adam Caplan of SiriusXM NFL Radio reports.

McCaffrey (Achilles/calf) is in uniform and expected to participate in Thursday's practice, Cam Inman of The San Jose Mercury News reports.

Coach Kyle Shanahan said McCaffrey (calf/Achilles) will be a limited practice participant Wednesday, Cam Inman of The San Jose Mercury News reports.

McCaffrey (Achilles/calf) appears to be a "long shot" to play Sunday against the Vikings, sources tell Ian Rapoport of NFL Network reports.

San Francisco head coach Kyle Shanahan labeled McCaffrey (calf/Achilles) as day-to-day heading into Sunday's game against the Vikings, Nick Wagoner of ESPN.com reports.