Mack had a workout with Arizona on Thursday, Howard Balzer of GoPHNX.com reports.
Mack (hamstring) was placed on injured reserve Tuesday, Aric DiLalla of the Broncos' official site reports.
Mack is expected to miss the Broncos' season finale against the Chargers on Sunday, Mike Klis of 9News Denver reports.
Mack suffered a hamstring injury during Sunday's game at Kansas City.
Mack rushed four times for 22 yards in Sunday's 51-14 loss to the Rams.
Mack rushed the ball five times for 37 yards in Sunday's 24-15 win over Arizona. He added four receptions on four targets for 26 yards.
Mack carried the ball three times for 15 yards and caught two of three targets for 62 yards and a touchdown in Sunday's 34-28 loss to Kansas City.
Mack rushed two times for three yards and secured his only target for six yards in Sunday's 10-9 loss to the Ravens.
Mack rushed two times for seven yards and secured his only target for five yards in Sunday's 23-10 loss to the Panthers.
Broncos head coach Nathaniel Hackett said Friday that Mack will have a role in the game plan in Sunday's matchup with the Panthers, Jeff Legwold of ESPN.com reports. "He's going to have to go in there and take advantage of this opportunity...he's got a little extra burst," Hackett said of Mack.