Juszczyk produced 26 rushing yards and a touchdown on five carries to go along with 19 receptions for 200 yards and a pair of scores while starting all 17 games for San Francisco this season.
Juszczyk (illness) is absent from the 49ers' injury report ahead of Monday's matchup with the Lions.
Juszczyk (illness) didn't practice Friday, Nick Wagoner of ESPN.com reports.
Juszczyk played 27 of the 49ers' 54 snaps on offense and went without a carry or target in Thursday's 12-6 loss to the Rams.
Juszczyk went without a carry or target while playing 25 of the 49ers' 64 offensive snaps in Sunday's 23-20 win over the Buccaneers.
Juszczyk (shoulder) was a full participant in Wednesday's practice session.
Juszczyk is considered day-to-day due to a shoulder injury, Cam Inman of The San Jose Mercury News reports.
Juszczyk recorded three receptions for 19 yards on five targets in Sunday's 23-17 loss to the 49ers.
Juszczyk had two receptions (three targets) for 40 yards in Monday's Week 1 win over the Jets.
Juszczyk and the 49ers have agreed to a restructured contract, Adam Schefter of ESPN reports.