Singleton (knee) was placed on injured reserve Wednesday.
Singleton suffered an ACL tear during Sunday's win over Tampa Bay, Nick Kosmider of The Athletic reports.
Singleton finished Sunday's 13-6 loss to the Steelers with 11 tackles (seven solo).
Singleton tallied nine tackles (six solo), including one interception, one pass defensed and one tackle for loss in Sunday's 26-20 loss to the Seahawks.
Singleton tallied a team-high four tackles (two solo) in Sunday's 34-30 preseason win over the Colts.
Singleton recorded 12 tackles (eight solo), including one sack in Sunday's 22-17 loss to the Texans.
Singleton recorded 10 tackles (four solo), one fumble recovery and one pass defended in Sunday's 29-12 win over the Browns.
Singleton recorded 16 tackles (11 solo) in Sunday's 21-20 win over the Vikings.
Singleton recorded 11 tackles (three solo) and a fumble recovery in Monday's 24-22 win over the Bills.
Singleton recorded 11 tackles (six solo) in the Broncos 19-17 victory over the Packers in Week 7.